Transition metal-free photocatalytic radical annulation of 2-cyanoaryl acrylamides with difluoromethyl radicals to assemble 4-amino-quinolinone derivatives
Wu Qiaoyan, Niuniu Zhang, Xirui Gong, Meilin Ren, Yanli Xü, Yanyan Chen
Abstract
A metal-free photocatalytic radical annulation of 2-cyanoaryl acrylamides with [CF 2 HPPh 3 ] + Br − to give 4-amino-quinolinones in good yields was developed. An easily obtained organophotocatalyst and green solvent acetone/H 2 O were utilized in the protocol.
Topics & Concepts
AnnulationChemistryRadicalPhotocatalysisAcetoneTransition metalSolventMetalMedicinal chemistryOrganic chemistryCatalysisRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsFluorine in Organic Chemistry