A plant nonenveloped double-stranded RNA virus activates and co-opts BNIP3-mediated mitophagy to promote persistent infection in its insect vector
Qifu Liang, Jiajia Wan, Huan Liu, Dongsheng Jia, Qian Chen, Aiming Wang, Tàiyún Wèi
Abstract
; SQSTM1: sequestosome 1; SRBSDV: southern rice black-streaked dwarf virus; STK11/LKB1: serine/threonine kinase 11; TOMM20: translocase of outer mitochondrial membrane 20; RBSDV: rice black-streaked dwarf virus; TUNEL: terminal deoxynucleotidyl dUTP nick end labeling; ULK1: unc-51 like autophagy activating kinase 1; VDAC1: voltage dependent anion channel 1.
Topics & Concepts
MitophagyBiologyAutophagyCell biologyATG8AMPKMitochondrionPINK1VirologyProtein kinase APhosphorylationBiochemistryApoptosisMosquito-borne diseases and controlPlant Virus Research StudiesAutophagy in Disease and Therapy