Salidroside alleviates acetaminophen-induced hepatotoxicity via Sirt1-mediated activation of Akt/Nrf2 pathway and suppression of NF-κB/NLRP3 inflammasome axis
Zhengshan Gao, Honghong Zhan, Wei Zong, Miaomiao Sun, Lang Linghu, Guowei Wang, Fancheng Meng, Min Chen
Topics & Concepts
SalidrosideInflammasomePharmacologyPI3K/AKT/mTOR pathwayLY294002Rhodiola roseaProtein kinase BChemistryOxidative stressAcetaminophenNF-κBApoptosisBiochemistryMedicineReceptorDrug-Induced Hepatotoxicity and ProtectionMedicinal Plants and Bioactive CompoundsOptimism, Hope, and Well-being