Stereoselective Diboration of Spirocyclobutenes: A Platform for the Synthesis of Spirocycles with Orthogonal Exit Vectors
Luis Nóvoa, Laura Trulli, Alejandro Parra, Mariola Tortosa
Abstract
Abstract The diastereo‐ and enantioselective diboration of spirocyclobutenes provides a platform for the rapid preparation of a wide variety of chiral spirocyclic building blocks. The chemoselective functionalization of the carbon‐boron bond in the products, including a stereospecific sp 3 ‐sp 2 Suzuki–Miyaura cross‐coupling reaction, provides a powerful tool to control the directionality and the nature of the exit vectors in the spirocyclic framework.
Topics & Concepts
Enantioselective synthesisStereoselectivityStereospecificitySurface modificationCombinatorial chemistryBoronChemistryCarbon fibersComputer scienceOrganic chemistryCatalysisAlgorithmPhysical chemistryComposite numberOrganoboron and organosilicon chemistryChemical Synthesis and AnalysisChemical synthesis and alkaloids