Novel GSH-responsive prodrugs derived from indole-chalcone and camptothecin trigger apoptosis and autophagy in colon cancer
Hui Wang, Caiyun Nie, Miao Liang Luo, Qiwen Bai, Zhentao Yao, Huifang Lv, Beibei Chen, Jianzheng Wang, Weifeng Xu, Saiqi Wang, Xiaobing Chen, Xiaobing Chen
Topics & Concepts
CamptothecinAutophagyProdrugApoptosisChemistryChalconeCancer cellPharmacologyTopoisomerasePaclitaxelMultiple drug resistanceReactive oxygen speciesTopoisomerase inhibitorCytotoxicityGlutathioneCancer researchCancerBiochemistryIn vitroBiologyStereochemistryGeneticsAntibioticsEnzymeCancer therapeutics and mechanisms14-3-3 protein interactionsSynthesis and biological activity