Litcius/Paper detail

PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism

Aileen A. Ren, Daniel Snellings, YouRong Sophie Su, Courtney C. Hong, Marco Castro, Alan T. Tang, Matthew R. Detter, Nicholas Hobson, Romuald Girard, Sharbel Romanos, Rhonda Lightle, Thomas Moore, Robert Shenkar, Christian Benavides, M. Makenzie Beaman, Helge Müller‐Fielitz, Mei Chen, Patricia Mericko, Jisheng Yang, Derek C. Sung, Michael T. Lawton, J. Michael Ruppert, Markus Schwaninger, Jakob Körbelin, Michael Potente, Issam A. Awad, Douglas A. Marchuk, Mark L. Kahn

2021Nature193 citationsDOIOpen Access PDF

Topics & Concepts

mTORC1Loss functionPI3K/AKT/mTOR pathwayCancer researchKLF4PTENVascular endothelial growth factorBiologyEffectorSuppressorCell biologyAngiogenesisCancerTranscription factorSignal transductionGeneGeneticsPhenotypeVEGF receptorsSOX2Vascular Malformations Diagnosis and TreatmentIntracerebral and Subarachnoid Hemorrhage ResearchVascular Malformations and Hemangiomas