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Maternal age enhances purifying selection on pathogenic mutations in complex I genes of mammalian mtDNA

Yanfei Ru, Xiaoling Deng, Jiatong Chen, Leping Zhang, Zhe Xu, Qunyu Lv, Shiyun Long, Zijian Huang, Minghua Kong, Jing Guo, Min Jiang

2024Nature Aging17 citationsDOI

Topics & Concepts

Mitochondrial DNABiologyNegative selectionGeneticsGeneMutationGermlineSelection (genetic algorithm)Transmission (telecommunications)GenomeComputer scienceEngineeringElectrical engineeringArtificial intelligenceMitochondrial Function and PathologyCRISPR and Genetic EngineeringRNA and protein synthesis mechanisms
Maternal age enhances purifying selection on pathogenic mutations in complex I genes of mammalian mtDNA | Litcius