Lipid nanoparticle-mediated silencing of osteogenic suppressor GNAS leads to osteogenic differentiation of mesenchymal stem cells in vivo
Genc Basha, Andrew Gregory Cottle, Thavaneetharajah Pretheeban, Karen Y. T. Chan, Dominik Witzigmann, Robert N. Young, Fábio Rossi, Pieter R. Cullis
Topics & Concepts
Mesenchymal stem cellGene silencingOsteoblastGNAS complex locusSmall interfering RNACell biologyTransfectionCancer researchRNA interferenceOsteoporosisBiologyIn vitroCell cultureRNAEndocrinologyGeneGeneticsRNA Interference and Gene DeliveryMicroRNA in disease regulationRNA Research and Splicing