Cell lineage-specific methylome and genome alterations in gout
Chia‐Chun Tseng, Wei‐Ting Liao, Man-Chun Wong, Chung‐Jen Chen, Su‐Chen Lee, Jeng‐Hsien Yen, Shun‐Jen Chang
Abstract
methylation were also associated with higher numbers of first-degree relatives who also had gout. The gouty-inflammation specific methylome and genome alterations could potentially aid in the identification of novel therapeutic targets.
Topics & Concepts
Lineage (genetic)DNA methylationGenomeBiologyComputational biologyEvolutionary biologyGeneticsGeneGene expressionGout, Hyperuricemia, Uric AcidDiet, Metabolism, and DiseaseMetabolism and Genetic Disorders