Elucidation of the relationship between evodiamine-induced liver injury and CYP3A4-mediated metabolic activation by UPLC-MS/MS analysis
Ting Peng, Jinqiu Rao, Tingting Zhang, Yuan Wang, Na Li, Qing Gao, Xinchi Feng, Zhaohui Song, Kai Wang, Feng Qiu
Topics & Concepts
GlutathioneCYP3A4PharmacologyChemistryLiver injuryButhionine sulfoximineCytochrome P450MicrosomeEnzymeMedicineBiochemistryQuinazolinone synthesis and applicationsPhenothiazines and Benzothiazines Synthesis and ActivitiesSynthesis and Biological Evaluation