Changes in body mass, appetite-related hormones, and appetite sensation in women during 4 days of hypobaric hypoxic exposure equivalent to 3,500-m altitude
Hannes Gatterer, Johanna Roche, Rachel Turner, Giovanni Vinetti, Giulia Roveri, Maja Schlittler, Michael Kob, Anna Walzl, Tomas Dal Cappello, Tadej Debevec, Christoph Siebenmann
Abstract
This study investigated the effects of hypoxia on appetite regulation in women while strictly controlling for diet, physical activity, menstrual cycle, and environmental conditions. In young women, 4 days of altitude exposure (3,500 m) decreases body weight and circulating acylated ghrelin levels while preserving leptin concentrations. In line with the hormonal changes, altitude exposure induces alterations in appetite sensation, consisting of a decreased feeling of hunger and prospective food intake and an increased feeling of fullness and satiety.
Topics & Concepts
AppetiteGhrelinInternal medicineEndocrinologyLeptinMedicinePeptide YYHypoxia (environmental)HormoneObesityChemistryNeuropeptideNeuropeptide Y receptorOxygenOrganic chemistryReceptorAdipose Tissue and MetabolismHigh Altitude and HypoxiaDiet and metabolism studies