Cell-penetrating peptides as facilitators of cargo-specific nanocarrier-based drug delivery
A. Jankowski, Matthew A. Ensign, Katharina Maisel
Abstract
their ability to aid in overcoming additional barriers such as the mucus layer, immune clearance, and non-specific accumulation. The design of NC-CPP drug delivery platforms involves consideration to the synergy between the NC type, cargo, target cell, and CPP. This review dives into recent developments of these platforms and into novel CPPs for NC drug delivery, also highlighting areas of future research. We cover a broad swath of the field, touching on novel instances and trends investigating the use of newly designed CPPs modulated for recognizing specific ligands for active targeting, NC-CPP combinations which tackle biological barriers such as the blood-brain barrier, and those with unique cargos from nucleic acids to proteins.