Litcius/Paper detail

Novel 1,3-diaryl pyrazole derivatives bearing methylsulfonyl moiety: Design, synthesis, molecular docking and dynamics, with dual activities as anti-inflammatory and anticancer agents through selectively targeting COX-2

Ahmed Shaker, Mai I. Shahin, Asmaa M. AboulMagd, Seham A. Abdel Aleem, Hamdy M. Abdel‐Rahman, Dalal A. Abou El Ella

2022Bioorganic Chemistry27 citationsDOI

Topics & Concepts

ChemistryCelecoxibDocking (animal)PyrazoleIC50In vivoAnti-inflammatoryPharmacologyMoietyMTT assayStereochemistryBiochemistryCell growthIn vitroMedicineBiologyNursingBiotechnologyInflammatory mediators and NSAID effectsSynthesis of β-Lactam CompoundsOrganic Chemistry Cycloaddition Reactions