Regulation of Multidrug Efflux Pumps by TetR Family Transcriptional Repressor Negatively Affects Secondary Metabolism in Streptomyces coelicolor A3(2)
Yukun Lei, Shumpei Asamizu, Takumi Ishizuka, Hiroyasu Onaka
Abstract
The bacterial metabolic potential to synthesize diverse secondary metabolites in the environment has been revealed by recent (meta)genomics of both unculturable and culturable bacteria. These studies imply that bacteria are continuously exposed to harmful chemical compounds in the environment. Streptomyces spp. contain antibiotic efflux pumps and SM biosynthetic gene clusters.
Topics & Concepts
Streptomyces coelicolorTetRBiologyEffluxComplementationStreptomycesATP-binding cassette transporterSecondary metabolismGeneticsMutantActinorhodinRepressorGeneBiochemistryTranscription factorBacteriaTransporterBiosynthesisMicrobial Natural Products and BiosynthesisAntibiotic Resistance in BacteriaMycobacterium research and diagnosis