Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop
Yichao Hua, Gerlanda Vella, Florian Rambow, Elizabeth Allen, Asier Antoranz, Marie Duhamel, Akira Takeda, Sirpa Jalkanen, Steffie Junius, Ann Smeets, David Nittner, Stefanie Dimmeler, Thomas Hehlgans, Adrian Liston, Francesca M. Bosisio, Giuseppe Floris, Damya Laoui, Maija Hollmén, Diether Lambrechts, Pascal Merchiers, Jean‐Christophe Marine, Susan Schlenner, Gabriele Bergers
Topics & Concepts
Immune systemBiologyLymphotoxinCD8Cancer researchImmunologyLymphocyteHigh endothelial venulesCytotoxic T cellT cellImmunotherapyCancer immunotherapyLymphotoxin beta receptorImmune checkpointTumor microenvironmentCell biologyBiochemistryIn vitroSingle-cell and spatial transcriptomicsImmune cells in cancerImmune Cell Function and Interaction