Elevation of plasma angiotensin II level is a potential pathogenesis for the critically ill COVID-19 patients
Zhiyong Wu, Rui Hu, Cuizhen Zhang, Wei Ren, Anfeng Yu, Xiaoyang Zhou
Abstract
Little is known about the mechanism of coronavirus disease 2019 (COVID-19)-induced critical illness and death. The host infection mediated by SARS-CoV-2 is mainly relied on ACE2 receptor. There is still a lack of clinical data about the effects of interaction of ACE2 and SARS-CoV-2 on RAS system and disease progression. We investigated the plasma angiotensin II (Ang II) and renin levels in 82 non-hypertensive patients (42 mild cases, 25 severe cases, and 15 critically ill cases) infected by SARS-CoV-2 and 12 critically ill patients not infected by SARS-CoV-2 serving as control.
Topics & Concepts
MedicineCritically illCoronavirus disease 2019 (COVID-19)Univariate analysisInternal medicineRenin–angiotensin systemPlasma renin activityCritical illnessPathogenesisSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Intensive care unitSeverity of illnessAngiotensin IIDiseasePlasma levelsMultivariate analysisGastroenterologyReceptorBlood pressureInfectious disease (medical specialty)COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 ResearchCOVID-19 Impact on Reproduction