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IBS randomized study: FODMAPs alter bile acids, phenolic- and tryptophan metabolites, while gluten modifies lipids

Elise Nordin, Per M. Hellström, Eddie Vuong, Anton Ribbenstedt, Carl Brunius, Rikard Landberg

2023American Journal of Physiology-Regulatory, Integrative and Comparative Physiology11 citationsDOI

Abstract

In irritable bowel syndrome (IBS), fermentable oligo-, di-, monosaccharides, and polyols (FODMAPs) affected microbial-derived metabolites relating to positive health outcomes such as reduced risk of colon cancer, inflammation, and type 2 diabetes, as shown in previous studies. The minor IBS symptom induction by FODMAP intake must be weighed against the positive health aspects of FODMAP consumption. Gluten affected lipids weakly with no association to IBS severity.

Topics & Concepts

Irritable bowel syndromeMetabolomeInternal medicineGlutenMetaboliteGastroenterologyMetabolomicsPlaceboCrossover studyMedicineChemistryBiochemistryChromatographyPathologyAlternative medicineGastrointestinal motility and disordersGut microbiota and healthDiet and metabolism studies
IBS randomized study: FODMAPs alter bile acids, phenolic- and tryptophan metabolites, while gluten modifies lipids | Litcius