Designing Mesoporous Silica Nanoparticles to Overcome Biological Barriers by Incorporating Targeting and Endosomal Escape
Miguel Gisbert-Garzarán, Daniel Lozano, Kotaro Matsumoto, Aoi Komatsu, Miguel Manzano, Fuyuhiko Tamanoi, María Vallet‐Regí
Abstract
cell cultures and a tumor-bearing chicken embryo model, demonstrating in all cases high biocompatibility and cytotoxic effect, efficient endosomal escape and tumor penetration, and accumulation in tumors grown on the chorioallantoic membrane of chicken embryos.
Topics & Concepts
EndosomeNanomedicineMesoporous silicaMaterials scienceInternalizationDrug deliveryNanotechnologyBiocompatibilityNanoparticleChorioallantoic membraneEndocytosisNanocarriersBiophysicsIn vitroCell biologyMesoporous materialCellIntracellularChemistryBiologyBiochemistryCatalysisMetallurgyNanoparticle-Based Drug DeliveryRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniques