Chemoselective Trimerization of Isocyanides: De Novo Synthesis of 2-Indole-Substituted Quinolines and Pyridines
Lan Bao, Yu Liu, Jinghan Peng, Yuan Wang, Jinhuan Dong, Xianxiu Xu
Abstract
A catalyst-free chemoselective trimerization reaction of readily available isocyanides is described. This domino reaction provides facile access to a wide range of 2-(indol-2-yl)-quinolines and 2-(indol-2-yl)-pyridines in moderate to excellent yields. A "head to head" heterodimerization of two isocyanides is proposed as the key step of this reaction.
Topics & Concepts
ChemistryIndole testIsocyanideDominoCatalysisCombinatorial chemistryCascade reactionReaction conditionsOrganic chemistryMulticomponent Synthesis of HeterocyclesCatalytic C–H Functionalization MethodsSynthesis of heterocyclic compounds