Lactate-induced M2 polarization of tumor-associated macrophages promotes the invasion of pituitary adenoma by secreting CCL17
Anke Zhang, Yuanzhi Xu, Houshi Xu, Jie Ren, Tong Meng, Yunjia Ni, Qingwei Zhu, Wen‐Bo Zhang, Yuanbo Pan, Jiali Jin, Yunke Bi, Zhe Wu, Shaojian Lin, Meiqing Lou
Abstract
M2 polarization. CCL17 levels in the TME are related to the PA invasiveness and clinical prognosis, and the CCL17/CCR4/mTOCR1 axis may serve as potential therapeutic targets for Pas.
Topics & Concepts
CCL17Tumor microenvironmentCancer researchChemokineImmune systemMedicineImmunologyCXCL10Pituitary Gland Disorders and TreatmentsImmune cells in cancerGlioma Diagnosis and Treatment