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Cancer-associated fibroblasts employ NUFIP1-dependent autophagy to secrete nucleosides and support pancreatic tumor growth

Meng Yuan, Bo Tu, Hengchao Li, Huanhuan Pang, Nan Zhang, Minghe Fan, Jingru Bai, Wei Wang, Zhaoqi Shu, Christopher C. DuFort, Sihan Huo, Jie Zhai, Ke Yao, Lina Wang, Haoqiang Ying, Wei‐Guo Zhu, Deliang Fu, Zeping Hu, Ying Zhao

2022Nature Cancer86 citationsDOI

Topics & Concepts

GlutamineAutophagyPancreatic cancerTumor microenvironmentStromaCancer-Associated FibroblastsCancer researchSecretionPancreatic tumorBiologyCancer cellInternal medicineCancerEndocrinologyChemistryCell biologyBiochemistryMedicineTumor cellsAmino acidImmunohistochemistryApoptosisCancer, Hypoxia, and MetabolismGenetics and Neurodevelopmental DisordersAutophagy in Disease and Therapy
Cancer-associated fibroblasts employ NUFIP1-dependent autophagy to secrete nucleosides and support pancreatic tumor growth | Litcius