Synthetic (<i>N</i>,<i>N</i>-Dimethyl)doxorubicin Glycosyl Diastereomers to Dissect Modes of Action of Anthracycline Anticancer Drugs
Dennis P. A. Wander, Sabina Y. van der Zanden, Merijn B. L. Vriends, Branca C. van Veen, Joey G. C. Vlaming, Thomas Bruyning, Thomas Hansen, Gijsbert A. van der Marel, Herman S. Overkleeft, Jacques Neefjes, Jeroen D. C. Codée
Abstract
-Dimethylepirubicin is identified as the most potent anthracycline that does not induce DNA damage while remaining cytotoxic.
Topics & Concepts
DoxorubicinAnthracyclineStereochemistryChemistryTopoisomeraseDaunorubicinGlycosylMoietyDNABiochemistryBiologyCancerChemotherapyGeneticsBreast cancerCancer therapeutics and mechanismsSynthetic Organic Chemistry MethodsSynthesis and Biological Evaluation