p53 Function and Dysfunction in Human Health and Diseases
Gabriella D’Orazi
Abstract
The p53 protein is a sequence-specific DNA-binding transcription factor that, in response to stressful stimuli, regulates gene expression related to multiple cellular functions including, but not limited to, cell cycle arrest, cell apoptosis, cell growth, DNA repair, cell metabolism, and the immune response [...].
Topics & Concepts
Cell cycleTranscription factorCell biologyDNA repairBiologyApoptosisGeneCell cycle checkpointImmune systemFunction (biology)CellDNADNA damageTranscription (linguistics)Cell functionCell growthCancer researchGeneticsPhilosophyLinguisticsCancer-related Molecular PathwaysCancer, Hypoxia, and MetabolismEpigenetics and DNA Methylation