Rh(III)-Catalyzed C–H Cyanation of 2<i>H</i>-Indazole with <i>N</i>-Cyano-<i>N</i>-phenyl-<i>p</i>-toluenesulfonamide
Jing Li, Linlin Shi, Shuping Zhang, Xuyan Wang, Xinju Zhu, Xin‐Qi Hao, Mao‐Ping Song
Abstract
-toluenesulfonamide has been realized via a chelation-assisted strategy. The methodology enables regioselective access to various ortho-cyanated phenylindazoles in good yields with a broad substrate scope and good functional group compatibility. The obtained cyanated indazoles could further be converted into other value-added chemicals. Importantly, the current protocol is featured with several characteristics, including a novel cyanating agent, good regioselectivity, and operational convenience.
Topics & Concepts
CyanationChemistryRegioselectivityIndazoleCatalysisCombinatorial chemistryMedicinal chemistryChelationSubstrate (aquarium)StereochemistryOrganic chemistryOceanographyGeologyCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsSynthesis and Catalytic Reactions