APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid
Na Zhao, Olivia N. Attrebi, Yingxue Ren, Wenhui Qiao, Berkiye Sonustun, Yuka A. Martens, Axel Meneses, Fuyao Li, Francis Shue, Jiaying Zheng, Alexandra J. Van Ingelgom, Mary Dabney Davis, Aishe Kurti, Joshua A. Knight, Cynthia Linares, Yixing Chen, Marion Delenclos, Chia‐Chen Liu, John Denis Fryer, Yan W. Asmann, Pamela J. McLean, Dennis W. Dickson, Owen A. Ross, Guojun Bu
Abstract
APOE4 exacerbates α-synuclein pathology in a synucleinopathy mouse model, and APOE4 genotype associates with increased α-synuclein pathology in humans.
Topics & Concepts
Amyloid (mycology)ToxicityMedicinePathologyAlpha-synucleinAmyloid βNeuroscienceInternal medicinePsychologyDiseaseParkinson's diseaseParkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatmentsCerebrovascular and genetic disorders