Chiral coordination polymer nanowires boost radiation-induced in situ tumor vaccination
Zhusheng Huang, Rong Gu, Shiqian Huang, Qian Chen, Jing Yan, Xiaoya Cui, Haojie Jiang, Dan Yao, Chuang Shen, Jiayue Su, Tao Liu, Jinhui Wu, Zhimin Luo, Yiqiao Hu, Ahu Yuan
Abstract
Abstract Radiation-induced in situ tumor vaccination alone is very weak and insufficient to elicit robust antitumor immune responses. In this work, we address this issue by developing chiral vidarabine monophosphate-gadolinium nanowires (aAGd-NWs) through coordination-driven self-assembly. We elucidate the mechanism of aAGd-NW assembly and characterize their distinct features, which include a negative surface charge, ultrafine topography, and right-handed chirality. Additionally, aAGd-NWs not only enhance X-ray deposition but also inhibit DNA repair, thereby enhancing radiation-induced in situ vaccination. Consequently, the in situ vaccination induced by aAGd-NWs sensitizes radiation enhances CD8 + T-cell-dependent antitumor immunity and synergistically potentiates the efficacy immune checkpoint blockade therapies against both primary and metastatic tumors. The well-established aAGd-NWs exhibit exceptional therapeutic capacity and biocompatibility, offering a promising avenue for the development of radioimmunotherapy approaches.