Metformin Protects ARPE-19 Cells from Glyoxal-Induced Oxidative Stress.
Sichang Qu, Chaoyang Zhang, Dandan Liu, Jing Wu, Haibin Tian, Lixia Lü, Guo‐Tong Xu, Fang Liu, Jingfa Zhang
Abstract
. Metformin exerted its protection against oxidative stress possibly via activating AMPK/Sirt1 and increasing TXNIP. Metformin has been proposed as a candidate drug for age-related macular degeneration (AMD) by both preclinical and clinical studies. The cellular and animal models used in this study might be useful for the interpretation of the molecular mechanisms involved in the drug activity.
Topics & Concepts
GlyoxalMetforminOxidative stressChemistryInternal medicineDiabetes mellitusMedicineEndocrinologyBiochemistryOrganic chemistryMetabolism, Diabetes, and CancerAdvanced Glycation End Products researchRetinal Diseases and Treatments