Synthesis, characterization, and <i>in vitro</i> anti-cholinesterase screening of novel indole amines
Humaira Yasmeen Gondal, Sobia Tariq, Shahzaib Akhter, Abdul Rauf Raza, Muhammad Fayyaz ur Rehman, Syeda Laila Rubab
Abstract
values for indole amines 25 and 24 (4.28 and 4.66 μM, respectively) were comparable to that of galantamine (4.15 μM) and may be studied further as cost-effective acetylcholinesterase inhibitors.
Topics & Concepts
Indole testIn vitroCholinesteraseChemistryCharacterization (materials science)Combinatorial chemistryPharmacologyOrganic chemistryBiochemistryMedicineNanotechnologyMaterials scienceCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsNicotinic Acetylcholine Receptors Study