Litcius/Paper detail

Chemically induced degradation of epigenetic targets

Md Kabir, Xufen Yu, H. Ümit Kanıskan, Jian Jin

2023Chemical Society Reviews27 citationsDOIOpen Access PDF

Abstract

effects. We highlight the mechanism of action of these degraders and their advantages in targeting both canonical and noncanonical functions of epigenetic targets in the context of cancer treatment. Furthermore, we present a future outlook for this exciting field. Overall, pharmacological degradation of epigenetic targets has emerged as an effective and attractive strategy to thwart cancer progression and growth.

Topics & Concepts

EpigeneticsComputational biologyEpigenesisBiologyDNA methylationGeneticsGeneGene expressionProtein Degradation and InhibitorsHistone Deacetylase Inhibitors ResearchEpigenetics and DNA Methylation