Recent Advances in Photocatalytic Decarboxylative Coupling Reactions in Medicinal Chemistry
Lindsay McMurray, Thomas M. McGuire, Rachel Howells
Abstract
This review covers recent advances in decarboxylative photocatalysis applicable to the medicinal chemist. The review is not intended to be exhaustive, but instead is focussed on transformations that could be useful in the synthesis of drug-like compounds in order to highlight the utility of this methodology in the development of new pharmaceutical candidates. 1 Introduction 2 C–C Bond Formation 3 C–N and C–O Bond Formation 4 Fluorination and Trifluoromethylation 5 Hydrodecarboxylation 6 Protein Functionalisation 7 Conclusion
Topics & Concepts
ChemistryTrifluoromethylationPhotocatalysisCombinatorial chemistryOrganic chemistryNanotechnologyCatalysisTrifluoromethylAlkylMaterials scienceRadical Photochemical ReactionsFluorine in Organic ChemistrySulfur-Based Synthesis Techniques