Development of non-viral vectors for neuronal-targeted delivery of CRISPR-Cas9 RNA-proteins as a therapeutic strategy for neurological disorders
Karim E. Shalaby, Mustapha Aouida, Vijay Gupta, Houari Abdesselem, Omar M. A. El‐Agnaf
Abstract
. This is a proof-of-concept towards simple and safe targeted genome-editing for treating PD and other neurological disorders.
Topics & Concepts
CRISPRCas9RNAComputational biologyViral vectorBiologyVirologyGeneticsRecombinant DNAGeneRNA Interference and Gene DeliveryCRISPR and Genetic EngineeringAdvanced biosensing and bioanalysis techniques