Novel isoniazid-hydrazone derivatives induce cell growth inhibition, cell cycle arrest and apoptosis via mitochondria-dependent caspase activation and PI3K/AKT inhibition
Khouloud Rouzi, Ahmet Altay, Mustapha Bouatia, Esma Yeniçeri, Mohammad Shahidul Islam, Afaf Oulmidi, Miloud El Karbane, Khalid Karrouchi
Topics & Concepts
ChemistryApoptosisPI3K/AKT/mTOR pathwayHydrazoneCaspaseCell biologyProtein kinase BCell cycle checkpointCell growthMitochondrionCaspase 3Cell cycleProgrammed cell deathCancer researchBiochemistryStereochemistryBiologySynthesis and biological activityGenomics, phytochemicals, and oxidative stressCancer therapeutics and mechanisms