CXCR4 mediates matrix stiffness-induced downregulation of UBTD1 driving hepatocellular carcinoma progression via YAP signaling pathway
Nan Yang, Tianxiang Chen, Liang Wang, Runkun Liu, Yongshen Niu, Liankang Sun, Bowen Yao, Yufeng Wang, Wei Yang, Qingguang Liu, Kangsheng Tu, Zhikui Liu
Abstract
: Our findings reveal CXCR4 as a molecular switch in mechano-transduction, thereby defining a mechano-signaling pathway from matrix stiffness to the nucleus.
Topics & Concepts
Epithelial–mesenchymal transitionChemokine receptorDownregulation and upregulationCell biologyChemistryCancer researchSignal transductionGene knockdownCXCR4ChemokineBiologyReceptorBiochemistryApoptosisGeneHippo pathway signaling and YAP/TAZUbiquitin and proteasome pathwaysCell death mechanisms and regulation