Development of Cu(<scp>ii</scp>)-specific peptide shuttles capable of preventing Cu–amyloid beta toxicity and importing bioavailable Cu into cells
Michael Okafor, Paulina González, Pascale Ronot, Islah El Masoudi, Anne Boos, Stéphane Ory, Sylvette Chasserot‐Golaz, Stéphane Gasman, Laurent Raibaut, Christelle Hureau, Nicolas Vitale, Peter Faller
Abstract
The synthetic peptide AKH-αR5W4 NBD was designed as a shuttle to counteract copper imbalance in Alzheimer’s disease. In vitro , this shuttle is able to abstract Cu( ii ) selectively from amyloid-β and transport it into cells in a bioavailable form.
Topics & Concepts
PeptideBioavailabilityIn vitroToxicityChemistryCopperAmyloid betaAmyloid (mycology)BiochemistryPharmacologyBiologyOrganic chemistryInorganic chemistryTrace Elements in HealthAlzheimer's disease research and treatmentsAdvanced biosensing and bioanalysis techniques