Afucosylation of HLA-specific IgG1 as a potential predictor of antibody pathogenicity in kidney transplantation
Pranay Bharadwaj, Sweta Shrestha, Tamás Pongrácz, Concetta Catalano, Shilpee Sharma, Alaín Le Moine, Noortje de Haan, Naoka Murakami, Leonardo V. Riella, Vanda Holovská, Manfred Wuhrer, Arnaud Marchant, Margaret E. Ackerman
Abstract
cells mediated by natural killer (NK) cells. Collectively, these results suggest that afucosylated DSA may be a biomarker of AMR and contribute to pathogenesis.
Topics & Concepts
ImmunologyAntibodyHuman leukocyte antigenPolyclonal antibodiesTransplantationCytotoxicityBiologyAntigenMonoclonal antibodyImmunoglobulin GPathogenesisMedicineBiochemistrySurgeryIn vitroRenal Transplantation Outcomes and TreatmentsComplement system in diseasesMonoclonal and Polyclonal Antibodies Research