A narrative review of the role of m6A in oxidative stress and inflammation

Abstract

Objective: To provide a comprehensive overview of the role and possible mechanism of N6-methyladenosine (m6A) in oxidative stress and inflammation. Background: Oxidative stress and inflammation are involved in many pathophysiological processes. How oxidative stress and inflammation participate in the occurrence and development of diseases, and what factors regulate them have not yet been clarified. In recent years, more and more attention has been paid to the research of m6A. Due to its extensive role in RNA internal modification and maintaining stability, more and more scientists began to study the relationship between m6A modification and diseases. However, the research about m6A on oxidative stress and inflammation is rare. Methods: We performed a systematic literature search of the MEDLINE literature database through PubMed on m6A, oxidative stress and inflammation. Subsequently, the main findings in the literature were summarized. Conclusions: Oxidative stress and inflammation are involved in many pathophysiological processes, including tumor, aging, diabetes, cardiovascular disease and so on. Post-transcriptional epigenetic modification of RNA mainly, m6A, is an emerging concept in the scientific community. m6A mediates its effect through the various reader, writer, and eraser proteins, regulating gene expression and involving many biological processes, including oxidative stress and inflammation. This article mainly reviews the role and molecular mechanism of m6A in the occurrence and development of many diseases by regulating oxidative stress and inflammation. There are many problems in the process of oxidative stress and inflammation, which are worthy of further study. m6A plays a key role in the occurrence and development of many diseases by regulating oxidative stress and inflammation. Keywords: N6-methyladenosine (m6A); oxidative stress; inflammation

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