1,3,4-Oxadiazole as a Potential Anti-Cancer Scaffold: A Review
Mohammad Sarwar Alam, Kamath Ghag, Reported, A Manikandan, S Antony, R Sridhar, S Ramakrishna, M Bououdina, K Chitra, A Manikandan, S Moortheswaran, K Reena, S Antony, A Subramanian, S Jaganathan, A Manikandan, K Pandiaraj, G Nageswaran, E Supriyanto, M Vellayappan, J Venugopal, S Ramakrishna, S Ray, A Ismail, M Mandal, A Manikandan, S Seal, S Jaganathan, M Vellayappan, S Jaganathan, A Manikandan, A Rehman, A Siddiqa, M Abbasi, S Rasool, S Siddiqui, I Ahmad, S Afzal, X Song, P Li, M Li, A Yang, L Yu, L Luo, D Hu, B Song, Wani, A Ahmad, R Shiekh, K Al-Ghamdi, A Sobral, A Othman, M Kihel, S Amara, L Zhou, P Wang, J Zhou, W Shao, H Fang, Z Wu, S Yang, Z Guo, Y Yin, C Wang, P Wang, X Zhang, Z Wang, H Zhu, Design, M Mullican, M Wilson, D Connor, C Kostlan, D Schrier, R Dyer, A Youssef, M White, E Villanueva, I El-Ashmawy, A Klegeris, B Jayashankar, K Rai, N Baskaran, H Sathish, F Ragab, S Abou-Seri, S Abdel-Aziz, A Alfayomy, M Aboelmagd, Design, J Mareddy, N Suresh, C Kumar, R Kapavarapu, A Jayasree, S Pal, D Kumar, G Patel, A Chavers, K Chang
Abstract
1,3,4-oxadiazole is an aromatic heterocycle with –N=C=O- linkage. 1,3,4-oxadiazole derivatives possess remarkable biological properties; antimicrobial anti-inflammatory, anti-cancer, antitubercular, antioxidant, antiviral, and anti-diabetic. This scaffold is present in many marketed drugs, such as Raltegravir, Tiodazosin, Nesapidil, and Zibotentan. 1,3,4-oxadiazole derivatives have displayed significant anti-cancer potential with a diverse mode of actions viz. growth factors, enzymes, kinases, etc. The present review gives an overview of the anti-cancer potential of 1,3,4-oxadiazoles derivatives in cancer drug discovery and development from the last ten years.