Design, synthesis and antitumor evaluation of novel 5-methylpyrazolo[1,5-a]pyrimidine derivatives as potential c-Met inhibitors
Guolin Luo, Yanxia Ma, Xintong Liang, Guoquan Xie, Yingqi Luo, Dailong Zha, Sheng Wang, Lihong Yu, Xuehua Zheng, Wenhao Wu, Chao Zhang
Topics & Concepts
ChemistryCytotoxicityCabozantinibPyrimidineStereochemistrySelectivityDocking (animal)KinaseIC50MoietyCell cultureStructure–activity relationshipA549 cellIn vitroBiochemistryCancer researchBiologyNursingVEGF receptorsCatalysisMedicineGeneticsLiver physiology and pathologyDrug Transport and Resistance MechanismsPancreatic and Hepatic Oncology Research