Mechanistic insights into chloramphenicol-mediated inactivation of cytochrome P450 enzymes and their active site mutants
Emadeldin M. Kamel, Ahmed M. Tawfeek, Ashraf A. El‐Bassuony, Al Mokhtar Lamsabhi
Abstract
Mechanistic aspects of the mechanism-based inactivation of cytochrome P450 enzymes by chloramphenicol.
Topics & Concepts
ChemistryChloramphenicolEnzymeMechanism (biology)Cytochrome P450MutantCytochromeBiochemistryGeneAntibioticsPhilosophyEpistemologyPharmacogenetics and Drug MetabolismDrug Transport and Resistance MechanismsCancer Treatment and Pharmacology