Sensitization of colonic nociceptors by IL-13 is dependent on JAK and p38 MAPK activity
Katie H. Barker, James P. Higham, Luke A. Pattison, Iain P. Chessell, Fraser Welsh, Ewan St. John Smith, David C. Bulmer
2023American Journal of Physiology-Gastrointestinal and Liver Physiology16 citationsDOIOpen Access PDF
Abstract
The pro-inflammatory cytokine interleukin-13 (IL-13) is elevated in gastrointestinal (GI) diseases. This study confirms a role for IL-13 in colonic afferent sensitization and defines a role for downstream Janus kinase (JAK) and p38 MAPK signaling in colonic mechanosensitization. It is shown that IL-13-mediated increase in [Ca2+]i in capsaicin-sensitive sensory neurons is dependent on p38 MAPK, and JAK signaling and IL-13-induced sensitization of colonic afferents to noxious mechanical distension is abolished by inhibition of p38 MAPK and JAK.
Topics & Concepts
Sensitizationp38 mitogen-activated protein kinasesNociceptorMAPK/ERK pathwayJanus kinaseMedicineCapsaicinSignal transductionCytokineChemistryInternal medicineImmunologyCell biologyNociceptionBiologyReceptorWhipple's Disease and InterleukinsIon Channels and ReceptorsIL-33, ST2, and ILC Pathways