Utility of Stool PCR for the Diagnosis of COVID-19: Comparison of Two Commercial Platforms
Wendy Szymczak, D. Goldstein, Erika P. Orner, Roger Fecher, Raquel T. Yokoda, Karin A. Skalina, Momka Narlieva, Inessa Gendlina, Amy S. Fox
Abstract
) values of >37 for the targets detected. Of the 48 patients with PCR-confirmed COVID-19, 23 were positive by both assays (47.9%). For the negative patient group, 2/29 were positive by both assays (6.9%). The two stool PCR-positive, nasopharyngeal/oropharyngeal PCR-negative patients were SARS-CoV-2 IgG positive. Our results demonstrate acceptable agreement between two commercially available molecular assays and support the use of stool PCR to confirm diagnosis when SARS-CoV-2 is undetectable in the upper respiratory tract.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakVirologyMedicineBetacoronavirusCoronavirus InfectionsPneumoniaMicrobiologyBiologyInternal medicineInfectious disease (medical specialty)OutbreakDiseaseSARS-CoV-2 detection and testingSARS-CoV-2 and COVID-19 ResearchViral gastroenteritis research and epidemiology