Cholesterol activates BK channels by increasing KCNMB1 protein levels in the plasmalemma
Anna N. Bukiya, M. Dennis Leo, Jonathan H. Jaggar, Alex M. Dopico
Abstract
mouse while activation was detected in their wild-type (C57BL/6) counterparts. In conclusion, the switch in CLR regulation of BK from inhibition to activation is determined by a trafficking-dependent increase in membrane levels of KCNMB1 subunits.
Topics & Concepts
ChemistryBiophysicsCholesterolBK channelCell biologyBiochemistryBiologyMembrane potentialIon channel regulation and functionCardiac electrophysiology and arrhythmiasIon Channels and Receptors