Bioinformatics analysis of the molecular mechanism of obesity in polycystic ovary syndrome
Jiaojiao Zhou, Xiaolin Huang, Bingshuang Xue, Yuhe Wei, Fei Hua
Abstract
BACKGROUND: Obesity is an important part of polycystic ovary syndrome (PCOS) pathologies. The present study utilized the bioinformatics method to identify the molecular mechanism of obesity status in PCOS. METHODS: < 0.05. The GO, KEGG pathway enrichment, and PPI network analysis were performed with the detected DEGs. RESULTS: = 0.0415). Further enrichment research demonstrated the CHRDL1 might function as an inhibitor of the BMP4 or IGF1 signalling. CONCLUSION: In summary, the present study identified CHRDL1 as a candidate gene responsible for the obesity of PCOS patients.
Topics & Concepts
Polycystic ovaryMechanism (biology)BioinformaticsBiologyMedicineComputational biologyObesityInternal medicineEndocrinologyInsulin resistancePhilosophyEpistemologyOvarian function and disordersReproductive Biology and FertilityLipid metabolism and disorders