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Design and synthesis of certain 7-Aryl-2-Methyl-3-Substituted Pyrazolo{1,5-a}Pyrimidines as multikinase inhibitors

Mustafa A. Al-Qadhi, Heba Abdelrasheed Allam, Samar H. Fahim, Tawfeek Ahmed Ali Yahya, Fatma A.F. Ragab

2023European Journal of Medicinal Chemistry17 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryStereochemistryIC50EnzymeDocking (animal)PharmacophoreArylCell cycle checkpointStructure–activity relationshipKinaseLead compoundApoptosisInhibitory postsynaptic potentialIn vitroCell cycleBiochemistryAlkylOrganic chemistryMedicineNeuroscienceNursingBiologyCancer Mechanisms and TherapyQuinazolinone synthesis and applicationsCancer therapeutics and mechanisms
Design and synthesis of certain 7-Aryl-2-Methyl-3-Substituted Pyrazolo{1,5-a}Pyrimidines as multikinase inhibitors | Litcius