Japanese Encephalitis Virus (JEV) NS1′ Enhances the Viral Infection of Dendritic Cells (DCs) and Macrophages in Pig Tonsils
Shengda Xie, Junhui Pan, Qiuting Zhang, Ruting Guan, Xingmiao Yang, Xiaoxiao Yang, Zhenjie Liang, Rui Cao
Abstract
Pigs are amplification hosts for Japanese encephalitis virus (JEV). JEV can persist in the tonsils for months despite the presence of neutralizing antibodies. The present study shows that NS1' increases JEV infection in pig tonsils. In addition, DCs and macrophages in the tonsils are the target cells for JEV infection, and JEV NS1' promotes virus infection in DCs and macrophages. This study reveals a novel function of JEV NS1' protein and lays the foundation for future studies of JEV persistent infection in pig tonsils.
Topics & Concepts
Japanese encephalitisVirologyVirusBiologyViral encephalitisFlavivirusImmunologyEncephalitisMosquito-borne diseases and controlViral Infections and VectorsViral Infections and Outbreaks Research