Metal-Free C–H/C–H Coupling of 2<i>H</i>-Imidazole 1-Oxides with Polyphenols toward Imidazole-Linked Polyphenolic Compounds
Timofey D. Moseev, Egor A. Nikiforov, Михаил В. Вараксин, Valery N. Charushin, Олег Н. Чупахин
Abstract
-imidazole 1-oxides. Comprehensive studies on the reaction condition optimization, scope, and limitations enabled the development of a straightforward method toward novel bifunctional derivatives bearing both phenolic and imidazole scaffolds of particular interest in the design of challenging molecules for versatile applications in medicinal chemistry and materials science.
Topics & Concepts
ImidazolePolyphenolBifunctionalChemistryNucleophileCombinatorial chemistryTransition metalPhenolsMoleculeOrganic chemistryMetalCatalysisAntioxidantCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSynthesis and Catalytic Reactions