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Fragment merging approach for the design of thiazole/thiazolidine clubbed pyrazoline derivatives as anti-inflammatory agents: Synthesis, biopharmacological evaluation and molecular modeling studies

Mohamed K. Elgohary, Soha R. Abd El Hadi, Mahmoud F. Abo-Ashour, Mohammed E. Abo‐El Fetoh, Hassan Afify, Hatem A. Abdel‐Aziz, Sahar M. Abou‐Seri

2023Bioorganic Chemistry25 citationsDOI

Topics & Concepts

ChemistryThiazoleThiazolidinePyrazolineIn vivoCelecoxibIC50PharmacologyStereochemistryCombinatorial chemistryAnti-inflammatoryBiochemistryIn vitroMedicinal chemistryMedicineBiologyBiotechnologySynthesis and biological activitySynthesis and Biological EvaluationInflammatory mediators and NSAID effects
Fragment merging approach for the design of thiazole/thiazolidine clubbed pyrazoline derivatives as anti-inflammatory agents: Synthesis, biopharmacological evaluation and molecular modeling studies | Litcius