An inhibitor with GSK3β and DYRK1A dual inhibitory properties reduces Tau hyperphosphorylation and ameliorates disease in models of Alzheimer's disease
Xin Liu, Lingyun Lai, Jiang-xia Chen, Xiang Li, Nan Wang, Lijun Zhou, Xiaowen Jiang, Xiaolong Hu, Wen-wu Liu, Xinming Jiao, Zhentong Qi, Wenjie Liu, Limeng Wu, Yaoguang Huang, Zihua Xu, Qingchun Zhao
Topics & Concepts
HyperphosphorylationTauopathyNeurodegenerationNeuropathologyPharmacologyIn vivoNeurofibrillary tangleHarmineNeuroscienceAlzheimer's diseaseChemistryTau proteinPhosphorylationDYRK1ASenile plaquesDiseaseBiologyMedicineBiochemistryInternal medicineBiotechnologyAlzheimer's disease research and treatments14-3-3 protein interactionsMicrotubule and mitosis dynamics