<i>Plasmodium falciparum pfhrp2</i> and <i>pfhrp3</i> Gene Deletions in Malaria-Hyperendemic Region, South Sudan
Irene Molina‐de la Fuente, María José Sagrado Benito, Laurence Flévaud, Janet Ousley, Harriet Akello Pasquale, Ahmed Julla, Abdirashid M. Abdi, Buai Tut Chol, Bakri Abubakr, Agustín Benito, Cristian Casademont, Carolina Nanclares, Pedro Berzosa
Abstract
Pfhrp2 and pfhrp3 gene deletions threaten the use of Plasmodium falciparum malaria rapid diagnostic tests globally. In South Sudan, deletion frequencies were 15.6% for pfhrp2, 20.0% for pfhrp3, and 7.5% for double deletions. Deletions were approximately twice as prevalent in monoclonal infections than in polyclonal infections.
Topics & Concepts
Plasmodium falciparumMalariaVirologyBiologyPolyclonal antibodiesGeneMonoclonalMonoclonal antibodyProtozoal diseaseGeneticsImmunologyAntibodyMalaria Research and ControlGenetics, Bioinformatics, and Biomedical Research