Copper-catalyzed remote asymmetric yne-allylic substitution: construction of thiazolone derivatives with adjacent chiral centers
Zihan Wang, Jia‐Run Wang, Yingying Wei, Bing Liu, Tao‐Yan Lin
Abstract
Herein, we report a highly diastereo- and enantioselective copper-catalyzed remote asymmetric yne-allylic substitution of yne-allylic esters and thiazolones.
Topics & Concepts
ChemistryAllylic rearrangementSubstitution (logic)CopperCatalysisSubstitution reactionMedicinal chemistryCombinatorial chemistryOrganic chemistryProgramming languageComputer scienceCatalytic C–H Functionalization MethodsAsymmetric Synthesis and CatalysisCatalytic Alkyne Reactions